Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study
Identifieur interne : 001680 ( Main/Exploration ); précédent : 001679; suivant : 001681Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an in vivo [11C]-harmine positron emission tomography study
Auteurs : Julia Sacher [Canada, Allemagne] ; Eugenii A. Rabiner [Canada] ; Michael Clark [Canada] ; Pablo Rusjan [Canada] ; Alexandra Soliman [Canada] ; Rada Boskovic [Canada] ; Stephen J. Kish [Canada] ; Alan A. Wilson [Canada] ; Sylvain Houle [Canada] ; Jeffrey H. Meyer [Canada]Source :
- Journal of Cerebral Blood Flow & Metabolism [ 0271-678X ] ; 2011.
English descriptors
- KwdEn :
- Carbidopa (administration & dosage), Carbidopa (blood), Carbidopa (pharmacology), Carbon Radioisotopes, Corpus Striatum (enzymology), Corpus Striatum (metabolism), Dopamine (metabolism), Dopamine Agonists (administration & dosage), Dopamine Agonists (blood), Dopamine Agonists (pharmacology), Drug Combinations, Harmine (metabolism), Humans, Levodopa (administration & dosage), Levodopa (blood), Levodopa (pharmacology), Monoamine Oxidase (metabolism), Parkinson Disease (enzymology), Positron-Emission Tomography, Prefrontal Cortex (enzymology), Prefrontal Cortex (metabolism), Protein Binding, Serotonin (metabolism), Substrate Specificity, Time Factors, Tryptophan (blood).
- MESH :
- chemical , administration & dosage : Carbidopa, Dopamine Agonists, Levodopa.
- chemical , blood : Carbidopa, Dopamine Agonists, Levodopa, Tryptophan.
- chemical , metabolism : Dopamine, Harmine, Monoamine Oxidase, Serotonin.
- chemical , pharmacology : Carbidopa, Dopamine Agonists, Levodopa.
- chemical : Carbon Radioisotopes, Drug Combinations.
- enzymology : Corpus Striatum, Parkinson Disease, Prefrontal Cortex.
- metabolism : Corpus Striatum, Prefrontal Cortex.
- Humans, Positron-Emission Tomography, Protein Binding, Substrate Specificity, Time Factors.
Abstract
Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [11C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A VT, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (
Url:
DOI: 10.1038/jcbfm.2011.184
PubMed: 22186668
PubMed Central: 3293124
Affiliations:
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Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H" last="Meyer">Jeffrey H. Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22186668</idno><idno type="pmc">3293124</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293124</idno><idno type="RBID">PMC:3293124</idno><idno type="doi">10.1038/jcbfm.2011.184</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">000003</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000003</idno><idno type="wicri:Area/Pmc/Curation">000003</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000003</idno><idno type="wicri:Area/Pmc/Checkpoint">000961</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000961</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000A96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A96</idno><idno type="wicri:Area/PubMed/Curation">000A96</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A96</idno><idno type="wicri:Area/PubMed/Checkpoint">000A96</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A96</idno><idno type="wicri:Area/Ncbi/Merge">001027</idno><idno type="wicri:Area/Ncbi/Curation">001027</idno><idno type="wicri:Area/Ncbi/Checkpoint">001027</idno><idno type="wicri:doubleKey">0271-678X:2011:Sacher J:dynamic:adaptive:changes</idno><idno type="wicri:Area/Main/Merge">001752</idno><idno type="wicri:Area/Main/Curation">001680</idno><idno type="wicri:Area/Main/Exploration">001680</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Dynamic, adaptive changes in MAO-A binding after alterations in substrate availability: an <italic>in vivo</italic> [<sup>11</sup>C]-harmine positron emission tomography study</title><author><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Day Clinic of Cognitive Neurology, University of Leipzig and Max-Planck-Institute for Cognition and Brain Sciences</institution>, Leipzig,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rabiner, Eugenii A" sort="Rabiner, Eugenii A" uniqKey="Rabiner E" first="Eugenii A" last="Rabiner">Eugenii A. Rabiner</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>GlaxoSmithKline</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>GlaxoSmithKline</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>The Clinical Pharmacology and Toxicology Division, The Hospital for Sick Children, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H" last="Meyer">Jeffrey H. Meyer</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Vivian M Rakoff PET Imaging Centre</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Mood and Anxiety Disorders Division, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto</institution>, Toronto,<country>Canada</country></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Journal of Cerebral Blood Flow & Metabolism</title><idno type="ISSN">0271-678X</idno><idno type="eISSN">1559-7016</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Carbidopa (administration & dosage)</term><term>Carbidopa (blood)</term><term>Carbidopa (pharmacology)</term><term>Carbon Radioisotopes</term><term>Corpus Striatum (enzymology)</term><term>Corpus Striatum (metabolism)</term><term>Dopamine (metabolism)</term><term>Dopamine Agonists (administration & dosage)</term><term>Dopamine Agonists (blood)</term><term>Dopamine Agonists (pharmacology)</term><term>Drug Combinations</term><term>Harmine (metabolism)</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (blood)</term><term>Levodopa (pharmacology)</term><term>Monoamine Oxidase (metabolism)</term><term>Parkinson Disease (enzymology)</term><term>Positron-Emission Tomography</term><term>Prefrontal Cortex (enzymology)</term><term>Prefrontal Cortex (metabolism)</term><term>Protein Binding</term><term>Serotonin (metabolism)</term><term>Substrate Specificity</term><term>Time Factors</term><term>Tryptophan (blood)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Carbidopa</term><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Carbidopa</term><term>Dopamine Agonists</term><term>Levodopa</term><term>Tryptophan</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term><term>Harmine</term><term>Monoamine Oxidase</term><term>Serotonin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Carbidopa</term><term>Dopamine Agonists</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Carbon Radioisotopes</term><term>Drug Combinations</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Corpus Striatum</term><term>Parkinson Disease</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Prefrontal Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Positron-Emission Tomography</term><term>Protein Binding</term><term>Substrate Specificity</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Monoamine oxidase A (MAO-A) is an important target in the pathophysiology and therapeutics of major depressive disorder, aggression, and neurodegenerative conditions. We measured the effect of changes in MAO-A substrate on MAO-A binding in regions implicated in affective and neurodegenerative disease with [<sup>11</sup>C]-harmine positron emission tomography in healthy volunteers. Monoamine oxidase A V<sub>T</sub>, an index of MAO-A density, was decreased (mean: 14%±9%) following tryptophan depletion in prefrontal cortex (<italic>P</italic><0.031), and elevated (mean: 17%±11%) in striatum following carbidopa–levodopa administration (<italic>P</italic><0.007). These findings suggest an adaptive role for MAO-A in maintaining monoamine neurotransmitter homeostasis by rapidly compensating fluctuating monoamine levels.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alia Klein, N" uniqKey="Alia Klein N">N Alia-Klein</name></author><author><name sortKey="Goldstein, Rz" uniqKey="Goldstein R">RZ Goldstein</name></author><author><name sortKey="Kriplani, A" uniqKey="Kriplani A">A Kriplani</name></author><author><name sortKey="Logan, J" uniqKey="Logan J">J Logan</name></author><author><name sortKey="Tomasi, D" uniqKey="Tomasi D">D Tomasi</name></author><author><name sortKey="Williams, B" uniqKey="Williams B">B Williams</name></author><author><name sortKey="Telang, F" uniqKey="Telang F">F Telang</name></author><author><name sortKey="Shumay, E" uniqKey="Shumay E">E Shumay</name></author><author><name sortKey="Biegon, A" uniqKey="Biegon A">A Biegon</name></author><author><name sortKey="Craig, Iw" uniqKey="Craig I">IW Craig</name></author><author><name sortKey="Henn, F" uniqKey="Henn F">F Henn</name></author><author><name sortKey="Wang, Gj" uniqKey="Wang G">GJ Wang</name></author><author><name sortKey="Volkow, Nd" uniqKey="Volkow N">ND Volkow</name></author><author><name sortKey="Fowler, Js" uniqKey="Fowler J">JS Fowler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De La Fuente Fernandez, R" uniqKey="De La Fuente Fernandez R">R de la Fuente-Fernandez</name></author><author><name sortKey="Lu, Jq" uniqKey="Lu J">JQ Lu</name></author><author><name sortKey="Sossi, V" uniqKey="Sossi V">V Sossi</name></author><author><name sortKey="Jivan, S" uniqKey="Jivan S">S Jivan</name></author><author><name sortKey="Schulzer, M" uniqKey="Schulzer M">M Schulzer</name></author><author><name sortKey="Holden, Je" uniqKey="Holden J">JE Holden</name></author><author><name sortKey="Lee, Cs" uniqKey="Lee C">CS Lee</name></author><author><name sortKey="Ruth, Tj" uniqKey="Ruth T">TJ Ruth</name></author><author><name sortKey="Calne, Db" uniqKey="Calne D">DB Calne</name></author><author><name sortKey="Stoessl, Aj" uniqKey="Stoessl A">AJ Stoessl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferrer, A" uniqKey="Ferrer A">A Ferrer</name></author><author><name sortKey="Artigas, F" uniqKey="Artigas F">F Artigas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fowler, Js" uniqKey="Fowler J">JS Fowler</name></author><author><name sortKey="Volkow, Nd" uniqKey="Volkow N">ND Volkow</name></author><author><name sortKey="Wang, Gj" uniqKey="Wang G">GJ Wang</name></author><author><name sortKey="Pappas, N" uniqKey="Pappas N">N Pappas</name></author><author><name sortKey="Logan, J" uniqKey="Logan J">J Logan</name></author><author><name sortKey="Shea, C" uniqKey="Shea C">C Shea</name></author><author><name sortKey="Alexoff, D" uniqKey="Alexoff D">D Alexoff</name></author><author><name sortKey="Macgregor, Rr" uniqKey="Macgregor R">RR MacGregor</name></author><author><name sortKey="Schlyer, Dj" uniqKey="Schlyer D">DJ Schlyer</name></author><author><name sortKey="Zezulkova, I" uniqKey="Zezulkova I">I Zezulkova</name></author><author><name sortKey="Wolf, Ap" uniqKey="Wolf A">AP Wolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ginovart, N" uniqKey="Ginovart N">N Ginovart</name></author><author><name sortKey="Meyer, Jh" uniqKey="Meyer J">JH Meyer</name></author><author><name sortKey="Boovariwala, A" uniqKey="Boovariwala A">A Boovariwala</name></author><author><name sortKey="Hussey, D" uniqKey="Hussey D">D Hussey</name></author><author><name sortKey="Rabiner, Ea" uniqKey="Rabiner E">EA Rabiner</name></author><author><name sortKey="Houle, S" uniqKey="Houle S">S Houle</name></author><author><name sortKey="Wilson, Aa" uniqKey="Wilson A">AA Wilson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lieben, 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A">AA Wilson</name></author><author><name sortKey="Houle, S" uniqKey="Houle S">S Houle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meyer, Jh" uniqKey="Meyer J">JH Meyer</name></author><author><name sortKey="Wilson, Aa" uniqKey="Wilson A">AA Wilson</name></author><author><name sortKey="Sagrati, S" uniqKey="Sagrati S">S Sagrati</name></author><author><name sortKey="Miler, L" uniqKey="Miler L">L Miler</name></author><author><name sortKey="Rusjan, Pm" uniqKey="Rusjan P">PM Rusjan</name></author><author><name sortKey="Bloomfield, Pm" uniqKey="Bloomfield P">PM Bloomfield</name></author><author><name sortKey="Clark, M" uniqKey="Clark M">M Clark</name></author><author><name sortKey="Sacher, J" uniqKey="Sacher J">J Sacher</name></author><author><name sortKey="Voineskos, An" uniqKey="Voineskos A">AN Voineskos</name></author><author><name sortKey="Houle, S" uniqKey="Houle S">S Houle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Neumeister, A" uniqKey="Neumeister A">A Neumeister</name></author><author><name sortKey="Nugent, Ac" uniqKey="Nugent A">AC Nugent</name></author><author><name sortKey="Waldeck, T" uniqKey="Waldeck T">T Waldeck</name></author><author><name sortKey="Geraci, M" uniqKey="Geraci M">M Geraci</name></author><author><name sortKey="Schwarz, M" uniqKey="Schwarz M">M Schwarz</name></author><author><name sortKey="Bonne, O" uniqKey="Bonne O">O Bonne</name></author><author><name sortKey="Bain, Ee" uniqKey="Bain E">EE Bain</name></author><author><name sortKey="Luckenbaugh, Da" uniqKey="Luckenbaugh D">DA Luckenbaugh</name></author><author><name sortKey="Herscovitch, P" uniqKey="Herscovitch P">P Herscovitch</name></author><author><name sortKey="Charney, Ds" uniqKey="Charney D">DS Charney</name></author><author><name sortKey="Drevets, Wc" uniqKey="Drevets W">WC Drevets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizzinat, N" uniqKey="Pizzinat N">N Pizzinat</name></author><author><name sortKey="Marchal Victorion, S" uniqKey="Marchal Victorion S">S Marchal-Victorion</name></author><author><name sortKey="Maurel, A" uniqKey="Maurel A">A Maurel</name></author><author><name sortKey="Ordener, C" uniqKey="Ordener C">C Ordener</name></author><author><name sortKey="Bompart, G" uniqKey="Bompart G">G Bompart</name></author><author><name sortKey="Parini, A" uniqKey="Parini A">A Parini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sacher, J" uniqKey="Sacher J">J Sacher</name></author><author><name sortKey="Wilson, Aa" uniqKey="Wilson A">AA Wilson</name></author><author><name sortKey="Houle, S" uniqKey="Houle S">S Houle</name></author><author><name sortKey="Rusjan, P" uniqKey="Rusjan P">P Rusjan</name></author><author><name sortKey="Hassan, S" uniqKey="Hassan S">S Hassan</name></author><author><name sortKey="Bloomfield, Pm" uniqKey="Bloomfield P">PM Bloomfield</name></author><author><name sortKey="Stewart, De" uniqKey="Stewart D">DE Stewart</name></author><author><name sortKey="Meyer, Jh" uniqKey="Meyer J">JH Meyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saura, J" uniqKey="Saura J">J Saura</name></author><author><name sortKey="Kettler, R" uniqKey="Kettler R">R Kettler</name></author><author><name sortKey="Da Prada, M" uniqKey="Da Prada M">M Da Prada</name></author><author><name sortKey="Richards, Jg" uniqKey="Richards J">JG Richards</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Youdim, Mb" uniqKey="Youdim M">MB Youdim</name></author><author><name sortKey="Edmondson, D" uniqKey="Edmondson D">D Edmondson</name></author><author><name sortKey="Tipton, Kf" uniqKey="Tipton K">KF Tipton</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name></noRegion><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Boskovic, Rada" sort="Boskovic, Rada" uniqKey="Boskovic R" first="Rada" last="Boskovic">Rada Boskovic</name><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><name sortKey="Clark, Michael" sort="Clark, Michael" uniqKey="Clark M" first="Michael" last="Clark">Michael Clark</name><name sortKey="Houle, Sylvain" sort="Houle, Sylvain" uniqKey="Houle S" first="Sylvain" last="Houle">Sylvain Houle</name><name sortKey="Kish, Stephen J" sort="Kish, Stephen J" uniqKey="Kish S" first="Stephen J" last="Kish">Stephen J. Kish</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H" last="Meyer">Jeffrey H. Meyer</name><name sortKey="Meyer, Jeffrey H" sort="Meyer, Jeffrey H" uniqKey="Meyer J" first="Jeffrey H" last="Meyer">Jeffrey H. Meyer</name><name sortKey="Rabiner, Eugenii A" sort="Rabiner, Eugenii A" uniqKey="Rabiner E" first="Eugenii A" last="Rabiner">Eugenii A. Rabiner</name><name sortKey="Rusjan, Pablo" sort="Rusjan, Pablo" uniqKey="Rusjan P" first="Pablo" last="Rusjan">Pablo Rusjan</name><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><name sortKey="Soliman, Alexandra" sort="Soliman, Alexandra" uniqKey="Soliman A" first="Alexandra" last="Soliman">Alexandra Soliman</name><name sortKey="Wilson, Alan A" sort="Wilson, Alan A" uniqKey="Wilson A" first="Alan A" last="Wilson">Alan A. Wilson</name></country><country name="Allemagne"><noRegion><name sortKey="Sacher, Julia" sort="Sacher, Julia" uniqKey="Sacher J" first="Julia" last="Sacher">Julia Sacher</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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